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Basic Concepts on Solid Phase Synthesis and Combinatorial Chemistry
Dr. Chandrakanta Bandyopadhyay
First Published: 2022
ISBN: 978-81-953189-0-2
Pages: 150

CONTENTS

- Chapter 1: Solid Phase Synthesis
- Chapter 2: Combinatorial Chemistry
- Chapter 3: Revisionary questions with short answers

ABOUT THE BOOK: This book is meant for M. Sc. & B. Sc. Hons/Major (CBCS) students of Chemistry. In the newly introduced CBCS curriculum 'Solid phase synthesis', 'Reagents on solid support and Combinatorial chemistry' are introduced into the B.Sc Honours and M.Sc curriculum of almost all universities. Combinatorial chemistry is a new branch of chemistry and is associated with drug discoveries in pharmaceutical industries. Earlier the drug discovery process was very slow, expensive, and laborious because screening was performed with each individual pure sample. After the discovery of combinatorial chemistry, this screening process can now be carried out with a mixture of samples without proper purification, and the success rate of finding lead compounds becomes much higher than in earlier processes. The development of combinatorial chemistry is largely made on the solid phase synthesis of the compound library. Syntheses of compound library and their de-convolution become easy when a compound is linked to a solid support. Solution phase synthesis of the combinatorial library is also possible but suffers from some disadvantages during synthesis and de-convolution. 
 
ABOUT THE AUTHOR: Dr. Chandrakanta Bandyopadhyay received his B.Sc., M.Sc., and Ph.D. degrees in Chemistry from the University of Calcutta in 1978, 1980, and 1987, respectively. He worked under the supervision of Late Prof. C. K. Ghosh for his doctoral degree. He joined the Department of Chemistry, Rama Krishna Mission Vivekananda Centenary College, Rahara, Kolkata as a junior lecturer in the Year 1984. At present, he is working as the Head of that department. He did his postdoctoral research in the Department of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan in 1991 with Prof. Ruben J. R. Hwu. His independent research interest lies in the chemistry of chromones, bichromones and bischromones; multicomponent reactions based on chromone skeleton in micellar media. He has published altogether 67 research papers in peer-reviewed national and international journals of which 52 with principal authorship. He has supervised five Ph.D. students for their Ph.D. degrees from the University of Calcutta. He authored a book entitled "An Insight into Green Chemistry" in May, 2019; the second edition of this book has been published in 2021 with Books & Allied (P) Ltd. He has been awarded: (i) Prof. Navneeth Rao Best Teacher Award in the year (2013) by A. V. Rama Rao Research Foundation, Hyderabad. (ii) Costal Chemical Research Society Award (Category C) in 2015. (iii) Certificate of Excellence in Teaching by UNICEF in 2021.